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Thus, GSH serves to reduce ROS, and both act as substrates in the detoxifying reaction

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Recent research has identified additional ferroptosis defense systems beyond the SLC7A11-GSH-GPX4 axis, including ferroptosis suppressor protein 1 (FSP1)/ubiquinone CoQ10/NAD(P)H, dihydroorotate dehydrogenase (DHODH)/CoQH2, cyclase GCH1/tetrahydrobiopterin (BH4), and ACSL3/MUFA-PL pathways [32]